Calpain A modulates Toll responses by limited Cactus/IκB proteolysis
نویسندگان
چکیده
منابع مشابه
Calpain A modulates Toll responses by limited Cactus/IκB proteolysis
Calcium-dependent cysteine proteases of the calpain family are modulatory proteases that cleave their substrates in a limited manner. Among their substrates, calpains target vertebrate and invertebrate IκB proteins. Because proteolysis by calpains potentially generates novel protein functions, it is important to understand how this affects NFκB activity. We investigate the action of Calpain A (...
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Pyruvate kinase is a key enzyme in glycolytic pathway that catalyzes the transphosphorylation between phosphoenolpyruvate and ADP to yield ATP and Pyruvate. Geobacillus stearothermophillus has a stable pyruvate kinase with determined crystal structure that composed of four separate domains. Given that limited proteolysis experiments can be successfully used to probe conformational features of p...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2013
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e13-02-0113